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Wall reinforcement

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4DVentral

Semi-resorbable parietal reinforcement implant

Partially resorbable extraperitoneal mesh for ventral hernias and incisional hernias.

4DVentral is a partially resorbable PP/PLLA implant for extraperitoneal reinforcement of ventral hernias and incisional hernias. The available sizes also make it possible to treat large and complex defects.
Composition: macroporous monofilament composite mesh in polypropylene (PP) and poly-L-lactic acid (PLLA)

4D Ventral / Ombilical
More information Instructions for use

Clinical benefits

Partially resorbable PP/PLLA implant with high initial stiffness for improved handling: provides high initial stability while reducing the implanted mass over the long term

  • Designed for ventral hernias and incisional hernias: covers a wide range of defect sizes in the extraperitoneal position
  • Macroporous, transparent structure: facilitates anatomical orientation and promotes tissue integration
  • Pro-regenerative and anti-inflammatory effects demonstrated in vitro: supports controlled tissue remodeling
  • Large sizes available: allow sufficient overlap even in the case of extensive defects
  • Complements 4DUmbilical and 4DMesh to provide a consistent 4D concept in abdominal wall surgery.

4DVentral is a partially resorbable PP/PLLA composite implant of intermediate weight, designed for the treatment of ventral hernias and incisional hernias. The PLLA component gives the mesh shape memory and initial stability, while the remaining PP component provides light but durable abdominal wall reinforcement. In vitro data have shown that this PP/PLLA composite directs the macrophage response toward an anti-inflammatory profile, supporting controlled tissue remodeling.

4DVentral is intended for extraperitoneal repair of ventral hernias and incisional hernias, whether primary ventral defects or large postoperative incisional hernias. Depending on the chosen technique (open, extraperitoneal laparoscopy, robot-assisted), 4DVentral can be used for medium to extensive defects, provided that an extraperitoneal position of the mesh is planned. It thus complements Intramesh® T1 and CA.B.S.’Air® Composite when extraperitoneal reconstruction is preferred over an intraperitoneal solution.

4DVentral is deployed extraperitoneally above the defect and oriented to ensure coverage with adequate overlap on healthy tissue. Depending on the approach (open, extraperitoneal laparoscopy, robot-assisted), the implant is progressively adapted to the abdominal wall. Fixation is generally performed with sutures and/or glue; for large defects, multiple fixation points are recommended. Flat variants can be trimmed to adapt the mesh surface to the geometry of the defect, while preserving the structural integrity of the implant.

For 4DVentral, in vitro data and registry analyses are available. In vitro, it has been shown that the PP/PLLA composite of 4DVentral® directs the macrophage response toward an anti-inflammatory profile, compatible with pro-regenerative tissue remodeling. Comparative data from the Club Hernie registry indicate shorter operating times and fewer early postoperative complications compared with competing meshes, with comparable and low recurrence and late complication rates.[1–2]

[1] Daoudi M et al. Br J Surg. 2022;109(Suppl.7).
[2] Club Hernie registry – comparative study 4DVentral® vs competing meshes, 2023.

Material: partially resorbable composite monofilament implant in polypropylene (PP) and poly-L-lactic acid (PLLA)

  • Weight: intermediate weight, weight after resorption approx. 65 ± 10 g/m²
  • Design: macroporous implant, intended for an extraperitoneal position, available in large sizes (e.g., 15 × 15 cm, 15 × 30 cm, 20 × 25 cm, 30 × 30 cm)
  • Application: extraperitoneal reinforcement of ventral hernias and incisional hernias.

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P-039 composite pp/plla monofilament 4dventral® promotes an anti-inflammatory response from human macrophages in vitro

Efficacy and safety of the 4dventral device for the treatment of ventral hernias by extraperitoneal approach, from the Club Hernia registry, 2024 – French

4DVentral – Product Sheet – English

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4DVentral is a Class III medical device, manufactured by COUSIN BIOTECH S.A.S. Its CE conformity assessment was carried out by the notified body DQS MED (CE0297). COUSIN BIOTECH S.A.S’s quality system has been certified as compliant with the requirements of ISO 13485.

Recommendations for use: Carefully read the labeling, instructions for use, and surgical technique before any intervention.

Wall reinforcement

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