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4DMesh

Semi-resorbable parietal reinforcement implant

Partially resorbable hernia prosthesis for laparoscopic and open management of inguinal and femoral hernias.

4DMesh is a partially resorbable monofilament implant intended for parietal reinforcement of inguinal and femoral hernias. The PP/PLLA composite combines the stability of a conventional polypropylene implant with a progressive reduction in the amount of implanted material in the long term. 4DMesh is suitable for open Lichtenstein repairs and TAPP and TEP laparoscopic techniques, with low recurrence and complication rates documented in clinical studies and registries.
Composition: composite macroporous monofilament mesh made of polypropylene (PP) and poly-L-lactic acid (PLLA)

Clinical benefits

Partially resorbable PP/PLLA structure (approximately 75% PLLA / 25% PP): high stability during the healing phase with reduction of permanent mass in the long term

  • Macro-porous and transparent design: facilitates anatomical orientation in open and laparoscopic surgery and promotes good tissue integration
  • Gentle “tack” effect related to PLLA, atraumatically repositionable implant
  • Documented clinical results: studies show a reduction in postoperative pain, lower seroma/hematoma rates, and very low recurrence rates in TEP and TAPP
  • Wide range of shapes and sizes: meshes for Lichtenstein, flat and anatomical implants for laparoscopy, enabling standardized management adapted to each procedure
  • Long-term comfort for patients: after PLLA resorption, a very lightweight PP mesh remains with minimal foreign body sensation
  • Flexible fixation concepts: can be used with reduced fixation or even without mechanical fixation, depending on the technique and clinical assessment.

4DMesh is a partially resorbable monofilament implant composed of PP and PLLA, with approximately 75% of the initial mass corresponding to resorbable PLLA and 25% to permanent PP. This material concept ensures the necessary mechanical stability in the early phase while reducing the material load in the long term. The macro-porosity and transparency of the knit facilitate anatomical orientation and tissue integration. The hydrophilicity of the PLLA component contributes to a gentle holding effect on the wall, without aggressive fixation systems.

4DMesh is designed for parietal reinforcement in inguinal and femoral hernias and covers a wide range of techniques: open Lichtenstein-type repair with right/left preformed meshes, TAPP and TEP laparoscopic procedures with flat or anatomical implants, and plug & patch approaches in combination with appropriate 4D components. 4DMesh thus offers a flexible solution for common and more complex situations in inguinal hernia surgery.

4DMesh is implanted in the extraperitoneal position and deploys easily, in both open and laparoscopic surgery, to conform to the abdominal wall. Flat variants can be cut to adapt the mesh size to the defect and anatomy. The implant is compatible with all common fixation methods (sutures, staples/clips, glue); clinical data show that 4DMesh can, in certain laparoscopic contexts, be used with reduced fixation or even without additional mechanical fixation, depending on defect size, technique, and surgical team experience.

For 4DMesh, several clinical studies and registry analyses are available, particularly in TEP and TAPP. Compared to standard PP implants, significantly shorter operative times, less postoperative pain, faster return to work, lower seroma/hematoma rates, and very low recurrence rates are observed. Registry data (notably Club Hernie) also show a higher proportion of asymptomatic patients and less moderate to severe pain at distance compared to competing implants, with comparable and low recurrence and infection rates.[1–4]
[1] Agca B et al. North Clin Istanb. 2019;6(4):388‑392.
[2] Kabaoglu B et al. Sisli Etfal Hastan Tip Bul. 2024;58(3):276‑283.
[3] Lund H et al. Surg Endosc. 2025;39(4):2464‑2470.
[4] Club Hernie Registry – comparative studies 2023 (4DMesh® anatomical, laparoscopic technique) and 2024 (4DMesh® vs competing meshes, Lichtenstein technique).

Material: composite monofilament implant made of poly-L-lactic acid (PLLA) and polypropylene (PP), approx. 75% PLLA (resorbable) / 25% PP (permanent)

  • Weight: approx. 30 ± 10 g/m² after resorption
  • Design: transparent macro-porous mesh, soft and highly flexible
  • Application: parietal reinforcement for the treatment of inguinal and femoral hernias; extraperitoneal implantation in open Lichtenstein-type surgery and TAPP/TEP laparoscopy
  • Shapes (examples): right/left preformed Lichtenstein implants (with/without flap), flat implants, TAPP/TEP anatomical implants, square/rectangular implants.

Resources

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Recurrence and complications after laparoscopic inguinal hernia repair using a self‑adherent mesh: a patient‑reported follow‑up study

Postoperative Outcomes and Recurrence Rate in Laparoscopic Tep Inguinal Hernia Repairs Using Partially Absorbable Meshes: A Retrospective Single-Surgeon Study Over a 5-Year Period

Early results of comparison of polypropylene mesh and 75% resorbable mesh (monofilament polypropylene and poly-L-lactic acid (PLLA) mesh) for laparoscopic total extraperitoneal (TEP) inguinal hernia repair

Laparoscopic transabdominal retromuscular ventral hernia repair (L‑TARUP): Outcomes from a single institution with mid‑term follow‑up

P-039 composite pp/plla monofilament 4dventral® promotes an anti-inflammatory response from human macrophages in vitro

4DMESH Anatomical / Comparative Study of Laparoscopic Technique from the Hernia Club Registry, 2023 – French

4DMesh Lichtenstein – Product Sheet – English

4D Mesh anatomical – Product Sheet – English

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4DMesh is a class III medical device manufactured by COUSIN BIOTECH S.A.S. Its CE conformity assessment was performed by the notified body DQS MED (CE0297). The quality system of COUSIN BIOTECH S.A.S has been certified compliant with the requirements of ISO 13485.

Recommendations for use: Carefully read the labeling, instructions for use, and surgical technique before any intervention.